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Pharmaceutical impurity

Lidocaine EP Impurity G

Lidocaine EP Impurity G is listed in the pharmaceutical impurity collection under CAS 42459-30-3. Its represented structure has formula C13H20N2O and a calculated molecular weight of 220.32 g/mol.

2D chemical structure

N H O N H

Chemical identity

Catalog name
Lidocaine EP Impurity G
Common name
Lidocaine EP Impurity G
Chemical name
N-(2,6-dimethylphenyl)-2-(propan-2-ylamino)acetamide
CAS
42459-30-3
SMILES
Cc1cccc(C)c1NC(=O)CNC(C)C
InChI
InChI=1S/C13H20N2O/c1-9(2)14-8-12(16)15-13-10(3)6-5-7-11(13)4/h5-7,9,14H,8H2,1-4H3,(H,15,16)
InChIKey
OAFINNSXFADGEF-UHFFFAOYSA-N
Associated API
Lidocaine

Record ID: Acb27da402396

Computed properties

C13H20N2O Molecular formula
220.316 g/molMolecular weight
220.1576 DaMonoisotopic exact mass
41.13 ŲTopological polar surface area
2.2399 Calculated LogP (Wildman–Crippen)
67.6844 cm³/molMolar refractivity (Wildman–Crippen)
2 countHydrogen-bond acceptors
2 countHydrogen-bond donors

Descriptors are calculated from the displayed SMILES. Calculated LogP is not a measured partition coefficient or a pH-specific LogD.

Molecular descriptor profile

Descriptor radar

Mol. weight LogP TPSA HBA HBD Rotatable 25 50 75 100

Structural feature counts

0 2 4 Count H-bond acceptors H-bond donors Rotatable bonds Rings Aromatic rings Stereo centers

Element composition

C H N O 0 5 10 15 20 Number of atoms

Radar scale: 0–100 percentile within 25,771 distinct represented structures in this release, using the midpoint rank for ties. Larger values indicate a higher descriptor rank, not greater safety or toxicity. Element counts include hydrogen and combine isotopes under each element.

Radar values and percentile reference
DescriptorValuePercentile
Molecular weight220.31622.71
Calculated LogP (Wildman–Crippen)2.239947.08
Topological polar surface area41.1323.12
Hydrogen-bond acceptors215.92
Hydrogen-bond donors264.87
Rotatable bonds (strict)449.39

Complete molecular descriptors

PropertyCalculated valueUnit / type
Molecular formulaC13H20N2Odimensionless
Molecular weight220.316g/mol
Monoisotopic exact mass220.1576Da
Topological polar surface area41.13Ų
Calculated LogP (Wildman–Crippen)2.2399dimensionless
Molar refractivity (Wildman–Crippen)67.6844cm³/mol
Hydrogen-bond acceptors2count
Hydrogen-bond donors2count
Rotatable bonds (strict)4count
Heavy atoms16count
Heteroatoms3count
Rings1count
Aromatic rings1count
Aliphatic rings0count
Saturated rings0count
Aromatic heterocycles0count
Aliphatic heterocycles0count
Saturated heterocycles0count
Aromatic carbocycles1count
Aliphatic carbocycles0count
Fraction of sp³ carbon atoms0.4615fraction
Formal charge0e
Disconnected components1count
Isotopically specified atoms0count
Potential atom stereocenters0count
Unspecified atom stereocenters0count
Spiro atoms0count
Bridgehead atoms0count
Labute approximate surface area97.2472Ų
Valence electrons88count
Radical electrons0count
Bertz complexity351.9454index
Balaban J2.6258index

Ring categories overlap and should not be summed. No toxicity result, PDE, HBEL or acceptable intake is inferred from these descriptors.

Toxicological services and resources for Lidocaine EP Impurity G

Qualification and safety assessment of Lidocaine EP Impurity G

Explore toxicological qualification of Lidocaine EP Impurity G and ICH M7 mutagenic impurity assessment of Lidocaine EP Impurity G for evaluation of this impurity in its pharmaceutical context.

Where data gaps need to be addressed, resources include read-across assessment for Lidocaine EP Impurity G and acceptable intake and limit justification for Lidocaine EP Impurity G. The relevant approach depends on the available evidence, exposure and duration of use.

Related Altox services and technical resources

Identity sources and calculation method

Identifiers originate from the source catalogues and available public identity records. InChI and InChIKey on this page are generated from the displayed SMILES. RDKit validation checks the molecular representation; it does not independently verify every catalogue assignment.

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